TY - JOUR
T1 - Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid
AU - Kirino, Izumi
AU - Fujita, Katsuhiko
AU - Sakanoue, Kei
AU - Sugita, Rin
AU - Yamagishi, Kento
AU - Takeoka, Shinji
AU - Fujie, Toshinori
AU - Uemoto, Shinji
AU - Morimoto, Yuji
N1 - Funding Information:
The authors thank W. Kayukawa, T. Takee, M. Ushida, Y. Mitsui and K. Aoki for technical assistance with the experiments and K. Eguchi, Y. Miyazono and R. Yamaguchi for fabrication of optoelectronic devices. The authors thank SES Translation and Editing Service (nt9s-chsh@asahi-net.or.jp) for English language editing. This work was supported by research grants from Uehara Memorial Foundation and from the Hitachi Global Foundation.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Metronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.
AB - Metronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.
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U2 - 10.1038/s41598-020-79067-7
DO - 10.1038/s41598-020-79067-7
M3 - Article
C2 - 33328544
AN - SCOPUS:85097604725
SN - 2045-2322
VL - 10
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 22017
ER -
