Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

Tomomi Marugame; Emiko Tsuji; Hisako Inoue; Sachiko Shinomiya; Chikako Kiyohara; Kazuya Onuma; Hiroaki Hamada; Hiroko Koga; Koichi Handa; Hitomi Hayabuchi; Suminori Kono

doi:10.1016/S0304-3835(99)00412-7

Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

Tomomi Marugame, Emiko Tsuji, Hisako Inoue, Sachiko Shinomiya, Chikako Kiyohara, Kazuya Onuma, Hiroaki Hamada, Hiroko Koga, Koichi Handa, Hitomi Hayabuchi, Suminori Kono

Social Medicine

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably associated with colorectal adenomas. The findings corroborate the lack of an association between the MTHFR genotype and colorectal adenomas, but do not deny the possibility that the genotype may be involved in the late stage of colorectal carcinogenesis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	181-186
Number of pages	6
Journal	Cancer Letters
Volume	151
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00412-7
Publication status	Published - Apr 14 2000

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00412-7

Cite this

@article{06aa0c756db3450387ec71343cf3541d,

title = "Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas",

abstract = "A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably associated with colorectal adenomas. The findings corroborate the lack of an association between the MTHFR genotype and colorectal adenomas, but do not deny the possibility that the genotype may be involved in the late stage of colorectal carcinogenesis. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

author = "Tomomi Marugame and Emiko Tsuji and Hisako Inoue and Sachiko Shinomiya and Chikako Kiyohara and Kazuya Onuma and Hiroaki Hamada and Hiroko Koga and Koichi Handa and Hitomi Hayabuchi and Suminori Kono",

note = "Funding Information: We are grateful to the ward nurses of the Self Defense Forces Fukuoka and Kumamoto Hospitals for their cooperation. This study was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports and Culture and from the Ministry of Health and Welfare, Japan.",

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doi = "10.1016/S0304-3835(99)00412-7",

language = "English",

volume = "151",

pages = "181--186",

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T1 - Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

AU - Marugame, Tomomi

AU - Tsuji, Emiko

AU - Inoue, Hisako

AU - Shinomiya, Sachiko

AU - Kiyohara, Chikako

AU - Onuma, Kazuya

AU - Hamada, Hiroaki

AU - Koga, Hiroko

AU - Handa, Koichi

AU - Hayabuchi, Hitomi

AU - Kono, Suminori

N1 - Funding Information: We are grateful to the ward nurses of the Self Defense Forces Fukuoka and Kumamoto Hospitals for their cooperation. This study was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports and Culture and from the Ministry of Health and Welfare, Japan.

PY - 2000/4/14

Y1 - 2000/4/14

N2 - A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably associated with colorectal adenomas. The findings corroborate the lack of an association between the MTHFR genotype and colorectal adenomas, but do not deny the possibility that the genotype may be involved in the late stage of colorectal carcinogenesis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably associated with colorectal adenomas. The findings corroborate the lack of an association between the MTHFR genotype and colorectal adenomas, but do not deny the possibility that the genotype may be involved in the late stage of colorectal carcinogenesis. Copyright (C) 2000 Elsevier Science Ireland Ltd.

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DO - 10.1016/S0304-3835(99)00412-7

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SN - 0304-3835

VL - 151

SP - 181

EP - 186

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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