"Metal-switched" molecular receptor site designed on a calix[4]arene platform

Hiroto Murakami; Seiji Shinkai

doi:10.1016/S0040-4039(00)60537-3

"Metal-switched" molecular receptor site designed on a calix[4]arene platform

Hiroto Murakami
, Seiji Shinkai

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

New calix[4]arene having a hydrogen-bonding receptor site near an ionophoric site was synthesized. The receptor site was activated from a "closed" form to an "open" form by the Na⁺-binding to the ionophoric site: that is, Na⁺ acts as a trigger for the "opening" of the molecular receptor site.

Original language	English
Pages (from-to)	4237-4240
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60537-3
Publication status	Published - Jun 25 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)60537-3

Cite this

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title = "{"}Metal-switched{"} molecular receptor site designed on a calix[4]arene platform",

abstract = "New calix[4]arene having a hydrogen-bonding receptor site near an ionophoric site was synthesized. The receptor site was activated from a {"}closed{"} form to an {"}open{"} form by the Na+-binding to the ionophoric site: that is, Na+ acts as a trigger for the {"}opening{"} of the molecular receptor site.",

author = "Hiroto Murakami and Seiji Shinkai",

note = "Funding Information: In conclusion, the present study demonstrated a “metal-switched” on-and-off system in molecular recognition. The behavior is similar to the allosteric effect frequently seen in a biological system. We are currently trying to design “switched-on” molecular receptors which feature more sensitive and more drastic changes in the guest-binding. This work was financially supported by Kurata Foundations.",

year = "1993",

month = jun,

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doi = "10.1016/S0040-4039(00)60537-3",

language = "English",

volume = "34",

pages = "4237--4240",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "26",

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TY - JOUR

T1 - "Metal-switched" molecular receptor site designed on a calix[4]arene platform

AU - Murakami, Hiroto

AU - Shinkai, Seiji

N1 - Funding Information: In conclusion, the present study demonstrated a “metal-switched” on-and-off system in molecular recognition. The behavior is similar to the allosteric effect frequently seen in a biological system. We are currently trying to design “switched-on” molecular receptors which feature more sensitive and more drastic changes in the guest-binding. This work was financially supported by Kurata Foundations.

PY - 1993/6/25

Y1 - 1993/6/25

N2 - New calix[4]arene having a hydrogen-bonding receptor site near an ionophoric site was synthesized. The receptor site was activated from a "closed" form to an "open" form by the Na+-binding to the ionophoric site: that is, Na+ acts as a trigger for the "opening" of the molecular receptor site.

AB - New calix[4]arene having a hydrogen-bonding receptor site near an ionophoric site was synthesized. The receptor site was activated from a "closed" form to an "open" form by the Na+-binding to the ionophoric site: that is, Na+ acts as a trigger for the "opening" of the molecular receptor site.

UR - https://www.scopus.com/pages/publications/0027158231

UR - https://www.scopus.com/pages/publications/0027158231#tab=citedBy

U2 - 10.1016/S0040-4039(00)60537-3

DO - 10.1016/S0040-4039(00)60537-3

M3 - Article

AN - SCOPUS:0027158231

SN - 0040-4039

VL - 34

SP - 4237

EP - 4240

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

"Metal-switched" molecular receptor site designed on a calix[4]arene platform

Abstract

All Science Journal Classification (ASJC) codes

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