Mesodermal and Hematopoietic Differentiation from ES and iPS Cells

Tomoko Inoue-Yokoo, Kenzaburo Tani, Daisuke Sugiyama

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.

Original languageEnglish
Pages (from-to)422-434
Number of pages13
JournalStem Cell Reviews and Reports
Issue number4
Publication statusPublished - Aug 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Cancer Research


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