Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Marwa Elsbaey, Amal Sallam, Mohamed El-Metwally, Maki Nagata, Chiaki Tanaka, Kuniyoshi Shimizu, Tomofumi Miyamoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Two new compounds, named 3,4-dimethoxyphenyl α-d-ribofuranoside (1) and 3β-(β-d-glucopyranosyloxy)olean-12-ene-23,28,30-trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one-, two-dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti-allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti-allergic activity in RBL-2H3 cells, as compared to quercetin.

Original languageEnglish
Article numbere1900237
JournalChemistry and Biodiversity
Issue number8
Publication statusPublished - Aug 2019

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology


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