TY - JOUR
T1 - Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami
AU - Elsbaey, Marwa
AU - Sallam, Amal
AU - El-Metwally, Mohamed
AU - Nagata, Maki
AU - Tanaka, Chiaki
AU - Shimizu, Kuniyoshi
AU - Miyamoto, Tomofumi
N1 - Funding Information:
We acknowledge the Eqyptian Ministry of Higher Education and Scientific Research for the post-doctoral fellowship granted to Marwa Elsbaey.
Publisher Copyright:
© 2019 Wiley-VHCA AG, Zurich, Switzerland
PY - 2019/8
Y1 - 2019/8
N2 - Two new compounds, named 3,4-dimethoxyphenyl α-d-ribofuranoside (1) and 3β-(β-d-glucopyranosyloxy)olean-12-ene-23,28,30-trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one-, two-dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti-allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti-allergic activity in RBL-2H3 cells, as compared to quercetin.
AB - Two new compounds, named 3,4-dimethoxyphenyl α-d-ribofuranoside (1) and 3β-(β-d-glucopyranosyloxy)olean-12-ene-23,28,30-trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one-, two-dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti-allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti-allergic activity in RBL-2H3 cells, as compared to quercetin.
UR - http://www.scopus.com/inward/record.url?scp=85069655214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069655214&partnerID=8YFLogxK
U2 - 10.1002/cbdv.201900237
DO - 10.1002/cbdv.201900237
M3 - Article
C2 - 31241824
AN - SCOPUS:85069655214
SN - 1612-1872
VL - 16
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 8
M1 - e1900237
ER -
