Melanin synthesis inhibitors from olea europeae

Amira Elkattan, Ahmed Gohar, Mohamed Amer, Zain M. Naeem, Ahmed Ashour, Kuniyoshi Shimizu

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The aim of this study was to discover more candidates for development of novel anti melanogenesis compounds from leaves of O. europeae. Seventeen compounds have been isolated from the leaves of O. europeae. The isolated compounds were identified as α, β-amyrin mixture (1), β-sitosterol (2), uvaol, erythrodiol mixture (3), oleanolic acid (4), maslinic acid (5), vomifoliol (6), β-sitosterol 3-O-β-D-glucoside (7), luteolin (8), oleoside dimethylester (9), oleuropein (10), hydroxypinoresinol 1-O-β-D-glucoside (11), luteolin-7-O-β-D-glucoside (12), diosmetin 7-O-β-D-glucoside (13), verbascoside (14), oleoside 11-methylester (15), secoxyloganin (16) and hydroxytyrosol 8-O-β-D-glucoside, hydroxytyrosol 4`-O-β-D-glucoside mixture (17). This is the first report on the identification of vomifoliol (6) in the oleaceae family. Results showed that several compounds other than oleuropein exhibited inhibition of melanin synthesis and at the same time with low cytotoxicity.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalRecords of Natural Products
Issue number2
Publication statusPublished - Mar 1 2019

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Plant Science
  • Pharmacology
  • Organic Chemistry


Dive into the research topics of 'Melanin synthesis inhibitors from olea europeae'. Together they form a unique fingerprint.

Cite this