Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

Hiroko Kodama; Suminori Kono; Ying Liu; Shizuka Sasazuki; Keitaro Tanaka; Shoji Tokunaga; Kouichi Yoshimasu; Masakazu Washio; Masahiro Mohri; Akira Takeshita; Kikuo Arakawa; Munehito Ideishi; Takanobu Nii; Kazuyuki Shirai; Koichi Handa; Keiichi Tanaka; Hidekazu Arai; Yoshitaka Doi; Tomoki Kawano; Osamu Nakagaki; Kazuyuki Takada; Yasushi Sasaki; Yasushi Ishihara; Tetsuji Inoh; Fumio Oshima; Tomoki Honma; Samon Koyanagi; Yasuo Hayashi; Yuji Maruoka; Yuji Taira; Ken Abe; Shunji Miake; Suguru Mori; Shinya Oda; Ryuichi Nagashima; Ichiro Ohmura; Tadayuki Hiroki; Ryuichiro Miyawaki; Juzabu Jinnouchi; Shinichiro Ito; Kazuyuki Saito; Terutoshi Tanioka; Kohzo Iino; Yasuhiro Maeda; Yasuhiko Orita; Yohsuke Katsuta; Hidero Nakazono; Naotaka Hamasaki; Hitomi Hayabuchi; Sumie Jingu; Ryoko Hayashi; Masako Sakamoto; Yoshiki Egashira; Tadashi Enomoto; Masanori Fujino; Keisuke Fukuda; Masakazu Gondo; Shouhei Hata; Satoshi Hiratsuka; Takashi Ichiki; Nariaki Ikeda; Yasuto Iwanaga; Hisashi Kanaya; Yoshihiro Kato; Masaki Kohara; Nobuo Masuda; Hideyo Matsuguchi; Eiichi Murayama; Masatsugu Ohga; Hideaki Ogushi; Nobuo Ouchi; Hiroshi Saku; Teizo Sata; Kuninori Soejima; Hiroshi Takamiya; Shinsuke Takei; Masafumi Tanaka; Noritami Tashiro; Takehiko Yamada; Tsutomu Yamamoto; Masato Yoshida

doi:10.1253/circj.66.463

Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

Hiroko Kodama, Suminori Kono, Ying Liu, Shizuka Sasazuki, Keitaro Tanaka, Shoji Tokunaga, Kouichi Yoshimasu, Masakazu Washio, Masahiro Mohri, Akira Takeshita, Kikuo Arakawa, Munehito Ideishi, Takanobu Nii, Kazuyuki Shirai, Koichi Handa, Keiichi Tanaka, Hidekazu Arai, Yoshitaka Doi, Tomoki Kawano, Osamu NakagakiKazuyuki Takada, Yasushi Sasaki, Yasushi Ishihara, Tetsuji Inoh, Fumio Oshima, Tomoki Honma, Samon Koyanagi, Yasuo Hayashi, Yuji Maruoka, Yuji Taira, Ken Abe, Shunji Miake, Suguru Mori, Shinya Oda, Ryuichi Nagashima, Ichiro Ohmura, Tadayuki Hiroki, Ryuichiro Miyawaki, Juzabu Jinnouchi, Shinichiro Ito, Kazuyuki Saito, Terutoshi Tanioka, Kohzo Iino, Yasuhiro Maeda, Yasuhiko Orita, Yohsuke Katsuta, Hidero Nakazono, Naotaka Hamasaki, Hitomi Hayabuchi, Sumie Jingu, Ryoko Hayashi, Masako Sakamoto, Yoshiki Egashira, Tadashi Enomoto, Masanori Fujino, Keisuke Fukuda, Masakazu Gondo, Shouhei Hata, Satoshi Hiratsuka, Takashi Ichiki, Nariaki Ikeda, Yasuto Iwanaga, Hisashi Kanaya, Yoshihiro Kato, Masaki Kohara, Nobuo Masuda, Hideyo Matsuguchi, Eiichi Murayama, Masatsugu Ohga, Hideaki Ogushi, Nobuo Ouchi, Hiroshi Saku, Teizo Sata, Kuninori Soejima, Hiroshi Takamiya, Shinsuke Takei, Masafumi Tanaka, Noritami Tashiro, Takehiko Yamada, Tsutomu Yamamoto, Masato Yoshida

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.

Original language	English
Pages (from-to)	463-468
Number of pages	6
Journal	Circulation Journal
Volume	66
Issue number	5
DOIs	https://doi.org/10.1253/circj.66.463
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1253/circj.66.463

Cite this

Kodama, H., Kono, S., Liu, Y., Sasazuki, S., Tanaka, K., Tokunaga, S., Yoshimasu, K., Washio, M., Mohri, M., Takeshita, A., Arakawa, K., Ideishi, M., Nii, T., Shirai, K., Handa, K., Tanaka, K., Arai, H., Doi, Y., Kawano, T., ... Yoshida, M. (2002). Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan. Circulation Journal, 66(5), 463-468. https://doi.org/10.1253/circj.66.463

Kodama, H, Kono, S, Liu, Y, Sasazuki, S, Tanaka, K, Tokunaga, S, Yoshimasu, K, Washio, M, Mohri, M, Takeshita, A, Arakawa, K, Ideishi, M, Nii, T, Shirai, K, Handa, K, Tanaka, K, Arai, H, Doi, Y, Kawano, T, Nakagaki, O, Takada, K, Sasaki, Y, Ishihara, Y, Inoh, T, Oshima, F, Honma, T, Koyanagi, S, Hayashi, Y, Maruoka, Y, Taira, Y, Abe, K, Miake, S, Mori, S, Oda, S, Nagashima, R, Ohmura, I, Hiroki, T, Miyawaki, R, Jinnouchi, J, Ito, S, Saito, K, Tanioka, T, Iino, K, Maeda, Y, Orita, Y, Katsuta, Y, Nakazono, H, Hamasaki, N, Hayabuchi, H, Jingu, S, Hayashi, R, Sakamoto, M, Egashira, Y, Enomoto, T, Fujino, M, Fukuda, K, Gondo, M, Hata, S, Hiratsuka, S, Ichiki, T, Ikeda, N, Iwanaga, Y, Kanaya, H, Kato, Y, Kohara, M, Masuda, N, Matsuguchi, H, Murayama, E, Ohga, M, Ogushi, H, Ouchi, N, Saku, H, Sata, T, Soejima, K, Takamiya, H, Takei, S, Tanaka, M, Tashiro, N, Yamada, T, Yamamoto, T & Yoshida, M 2002, 'Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan', Circulation Journal, vol. 66, no. 5, pp. 463-468. https://doi.org/10.1253/circj.66.463

@article{8b2b55548c9f4a29a4fab082bae78486,

title = "Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan",

abstract = "While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.",

author = "Hiroko Kodama and Suminori Kono and Ying Liu and Shizuka Sasazuki and Keitaro Tanaka and Shoji Tokunaga and Kouichi Yoshimasu and Masakazu Washio and Masahiro Mohri and Akira Takeshita and Kikuo Arakawa and Munehito Ideishi and Takanobu Nii and Kazuyuki Shirai and Koichi Handa and Keiichi Tanaka and Hidekazu Arai and Yoshitaka Doi and Tomoki Kawano and Osamu Nakagaki and Kazuyuki Takada and Yasushi Sasaki and Yasushi Ishihara and Tetsuji Inoh and Fumio Oshima and Tomoki Honma and Samon Koyanagi and Yasuo Hayashi and Yuji Maruoka and Yuji Taira and Ken Abe and Shunji Miake and Suguru Mori and Shinya Oda and Ryuichi Nagashima and Ichiro Ohmura and Tadayuki Hiroki and Ryuichiro Miyawaki and Juzabu Jinnouchi and Shinichiro Ito and Kazuyuki Saito and Terutoshi Tanioka and Kohzo Iino and Yasuhiro Maeda and Yasuhiko Orita and Yohsuke Katsuta and Hidero Nakazono and Naotaka Hamasaki and Hitomi Hayabuchi and Sumie Jingu and Ryoko Hayashi and Masako Sakamoto and Yoshiki Egashira and Tadashi Enomoto and Masanori Fujino and Keisuke Fukuda and Masakazu Gondo and Shouhei Hata and Satoshi Hiratsuka and Takashi Ichiki and Nariaki Ikeda and Yasuto Iwanaga and Hisashi Kanaya and Yoshihiro Kato and Masaki Kohara and Nobuo Masuda and Hideyo Matsuguchi and Eiichi Murayama and Masatsugu Ohga and Hideaki Ogushi and Nobuo Ouchi and Hiroshi Saku and Teizo Sata and Kuninori Soejima and Hiroshi Takamiya and Shinsuke Takei and Masafumi Tanaka and Noritami Tashiro and Takehiko Yamada and Tsutomu Yamamoto and Masato Yoshida",

year = "2002",

doi = "10.1253/circj.66.463",

language = "English",

volume = "66",

pages = "463--468",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "5",

}

TY - JOUR

T1 - Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

AU - Kodama, Hiroko

AU - Kono, Suminori

AU - Liu, Ying

AU - Sasazuki, Shizuka

AU - Tanaka, Keitaro

AU - Tokunaga, Shoji

AU - Yoshimasu, Kouichi

AU - Washio, Masakazu

AU - Mohri, Masahiro

AU - Takeshita, Akira

AU - Arakawa, Kikuo

AU - Ideishi, Munehito

AU - Nii, Takanobu

AU - Shirai, Kazuyuki

AU - Handa, Koichi

AU - Tanaka, Keiichi

AU - Arai, Hidekazu

AU - Doi, Yoshitaka

AU - Kawano, Tomoki

AU - Nakagaki, Osamu

AU - Takada, Kazuyuki

AU - Sasaki, Yasushi

AU - Ishihara, Yasushi

AU - Inoh, Tetsuji

AU - Oshima, Fumio

AU - Honma, Tomoki

AU - Koyanagi, Samon

AU - Hayashi, Yasuo

AU - Maruoka, Yuji

AU - Taira, Yuji

AU - Abe, Ken

AU - Miake, Shunji

AU - Mori, Suguru

AU - Oda, Shinya

AU - Nagashima, Ryuichi

AU - Ohmura, Ichiro

AU - Hiroki, Tadayuki

AU - Miyawaki, Ryuichiro

AU - Jinnouchi, Juzabu

AU - Ito, Shinichiro

AU - Saito, Kazuyuki

AU - Tanioka, Terutoshi

AU - Iino, Kohzo

AU - Maeda, Yasuhiro

AU - Orita, Yasuhiko

AU - Katsuta, Yohsuke

AU - Nakazono, Hidero

AU - Hamasaki, Naotaka

AU - Hayabuchi, Hitomi

AU - Jingu, Sumie

AU - Hayashi, Ryoko

AU - Sakamoto, Masako

AU - Egashira, Yoshiki

AU - Enomoto, Tadashi

AU - Fujino, Masanori

AU - Fukuda, Keisuke

AU - Gondo, Masakazu

AU - Hata, Shouhei

AU - Hiratsuka, Satoshi

AU - Ichiki, Takashi

AU - Ikeda, Nariaki

AU - Iwanaga, Yasuto

AU - Kanaya, Hisashi

AU - Kato, Yoshihiro

AU - Kohara, Masaki

AU - Masuda, Nobuo

AU - Matsuguchi, Hideyo

AU - Murayama, Eiichi

AU - Ohga, Masatsugu

AU - Ogushi, Hideaki

AU - Ouchi, Nobuo

AU - Saku, Hiroshi

AU - Sata, Teizo

AU - Soejima, Kuninori

AU - Takamiya, Hiroshi

AU - Takei, Shinsuke

AU - Tanaka, Masafumi

AU - Tashiro, Noritami

AU - Yamada, Takehiko

AU - Yamamoto, Tsutomu

AU - Yoshida, Masato

PY - 2002

Y1 - 2002

N2 - While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.

AB - While lowering the blood cholesterol level has been shown to decrease the risk of coronary heart disease (CHD) in Western countries, little is known about the relationship between lipid-lowering drugs and CHD risk in Japan. A case-control study of nonfatal acute myocardial infarction (AMI) was conducted in Japan. A total of 658 cases aged 40-79 years and 1,274 community controls matched to each case by sex, year of birth, and residence were compared for their use of lipid-lowering drugs and level of serum total cholesterol. The study used 2 definitions of hypercholesterolemia: (i) either serum total cholesterol ≥6.21 mmol/L (240 mg/dl) or current use of hypolipidemic drugs; and (ii) either serum total cholesterol of ≥5.69 mmol/L (220 mg/dl) or current use of hypolipidemic drugs. Unconditional logistic regression analysis was used to adjust for hypertension, angina pectoris, diabetes mellitus, smoking, alcohol use, and physical activity as well as for sex and age. As compared with nonhypercholesterolemic subjects, those with untreated hypercholesterolemia had a significantly increased risk of AMI whereas no increase in the risk was observed for treated hypercholesterolemia. In the group with hypercholesterolemia, regardless of the definition, the adjusted odds ratios decreased progressively when the achieved cholesterol levels were lower.

UR - http://www.scopus.com/inward/record.url?scp=0036257651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036257651&partnerID=8YFLogxK

U2 - 10.1253/circj.66.463

DO - 10.1253/circj.66.463

M3 - Article

C2 - 12030341

AN - SCOPUS:0036257651

SN - 1346-9843

VL - 66

SP - 463

EP - 468

JO - Circulation Journal

JF - Circulation Journal

IS - 5

ER -

Medication for hypercholesterolemia and the risk of nonfatal acute myocardial infarction - A case-control study in Japan

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this