Mediastinal paraganglioma

Yoko Takashima, Takeshi Kamitani, Satoshi Kawanami, Michinobu Nagao, Masato Yonezawa, Yuzo Yamasaki, Shingo Baba, Hidetake Yabuuchi, Tomoyuki Hida, Kenichi Kohashi, Katsuya Nakamura, Hiromichi Sonoda, Yoshinao Oda, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


We present a case of mediastinal paraganglioma with radiologic–pathologic correlation. A 48-year-old woman was found incidentally to have a middle mediastinal mass on CT. The mass showed iso-signal intensity compared to that of muscle on T1-weighted images and high signal intensity on T2-weighted images. The lesion showed intermediate intensity on diffusion-weighted imaging, and its apparent diffusion coefficient was 1.72 × 10−3 mm2/s. A contrast-enhanced dynamic study revealed a rapid peak and washout enhancement pattern. 18F-FDG-PET revealed abnormal uptake in the mediastinal tumor with a maximal standardized uptake value of 7.88. 123I-meta-iodobenzylguanidine scintigraphy also showed abnormal uptake in the tumor. These findings corresponded to the hypervascularity, rich stroma, low nuclear/cytoplasmic ratio, and nest-forming proliferation of tumor cells with positive neuroendocrine markers.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalJapanese Journal of Radiology
Issue number7
Publication statusPublished - Jul 25 2015

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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