TY - JOUR
T1 - Mechanisms underlying increased vascular smooth muscle contractility in the rabbit basilar artery following subarachnoid hemorrhage
AU - Kikkawa, Yuichiro
AU - Kameda, Katsuharu
AU - Matsuo, Satoshi
AU - Kurogi, Ryota
AU - Nakamizo, Akira
AU - Mizoguchi, Masahiro
AU - Sasaki, Tomio
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - Increased vascular contractility plays an important role in the development of cerebral vasospasm following subarachnoid hemorrhage (SAH). Here, we summarize our current knowledge regarding molecular mechanisms that contribute to increased smooth muscle contractility of rabbit basilar artery following SAH. Our studies demonstrated that upregulation of receptor expression, impairment of feedback regulation of receptor activity, and enhancement of myofilament Ca2+ sensitization might lead to increased smooth muscle contractility following SAH.
AB - Increased vascular contractility plays an important role in the development of cerebral vasospasm following subarachnoid hemorrhage (SAH). Here, we summarize our current knowledge regarding molecular mechanisms that contribute to increased smooth muscle contractility of rabbit basilar artery following SAH. Our studies demonstrated that upregulation of receptor expression, impairment of feedback regulation of receptor activity, and enhancement of myofilament Ca2+ sensitization might lead to increased smooth muscle contractility following SAH.
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U2 - 10.1007/978-3-319-04981-6_16
DO - 10.1007/978-3-319-04981-6_16
M3 - Article
C2 - 25366606
AN - SCOPUS:84921663220
SN - 0065-1419
VL - 120
SP - 95
EP - 98
JO - Acta Neurochirurgica, Supplementum
JF - Acta Neurochirurgica, Supplementum
ER -