Mechanisms of resistance to penicillins in Enterococcus faecalis

Noriyuki Hiraga, Tetsuro Muratani, Kaoru Shiozaki, Shizuka Lee, Seiji Ono, Tetsuro Matsumoto, Shunichi Kajioka, Seiji Naito, Tomoko Kobayashi, Haruhisa Saku

Research output: Contribution to journalArticlepeer-review


Penicillins are commonly used in the treatment of a wide range of infections and are often used for therapy in patients with urinary tract infections. Enterococcus faecalis is susceptible to penicillins and there have been only a few reports about penicillin-resistant E. faecalis. Three mechanisms of penicillin resistance have been reported in E. faecalis ; one is the production of beta-lactamase, another is overproduction of penicillin-binding protein (PBP) 4 or PBP5, and the third is decreasing affinities of penicillins for PBP4 by the occurrence of point mutations in the penicillin-recognition domain. In this article, we reviewed the mechanisms of resistance to penicillins in E. faecalis.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalNishinihon Journal of Urology
Issue number2
Publication statusPublished - Feb 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Urology


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