TY - JOUR
T1 - Mechanism of demyelination in the guinea pig - Separate sensitization with encephalitogenic myelin basic protein and nonencephalitogenic brain components
AU - Driscoll, Bernard F.
AU - Kira, Junichi
AU - Kies, Marian W.
AU - Alvord, Ellsworth C.
PY - 1986/2/1
Y1 - 1986/2/1
N2 - Experimental allergic encephalomyelitis (EAE), accompanied by demyelinating central nervous system (CNS) lesions, can be induced in guinea pigs sensitized with whole guinea pig CNS tissue, but not in animals sensitized with purified myelin basic protein (BP). This type of chronic demyelinating EAE is presumably a result of a combination of a cell-mediated immune response to the encephalitogenic BP and a separate response to other nonencephalitogenic CNS antigens. We report here that demyelinating EAE can be induced when separate sensitizations are used to induce a cell-mediated response to BP and a second immune response to nonencephalitogenic CNS antigens. Animals sensitized in separate sites with guinea pig BP and whole chicken brain develop CNS demyelinating lesions. Animals sensitized only to BP or chicken brain do not develop demyelination. The antigen(s) responsible for demyelination are found in the myelin fraction of chicken brain.
AB - Experimental allergic encephalomyelitis (EAE), accompanied by demyelinating central nervous system (CNS) lesions, can be induced in guinea pigs sensitized with whole guinea pig CNS tissue, but not in animals sensitized with purified myelin basic protein (BP). This type of chronic demyelinating EAE is presumably a result of a combination of a cell-mediated immune response to the encephalitogenic BP and a separate response to other nonencephalitogenic CNS antigens. We report here that demyelinating EAE can be induced when separate sensitizations are used to induce a cell-mediated response to BP and a second immune response to nonencephalitogenic CNS antigens. Animals sensitized in separate sites with guinea pig BP and whole chicken brain develop CNS demyelinating lesions. Animals sensitized only to BP or chicken brain do not develop demyelination. The antigen(s) responsible for demyelination are found in the myelin fraction of chicken brain.
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U2 - 10.1007/BF02834295
DO - 10.1007/BF02834295
M3 - Article
C2 - 2423932
AN - SCOPUS:0022671410
SN - 0734-600X
VL - 4
SP - 11
EP - 22
JO - Neurochemical Pathology
JF - Neurochemical Pathology
IS - 1
ER -