Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase

Tetsuro Ago, Hiroyuki Nunoi, Takashi Ito, Hideki Sumimoto

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203 Citations (Scopus)

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Biochemistry, Genetics and Molecular Biology