Mechanical properties of a giant liposome studied using optical tweezers

Yoko Shitamichi, Masatoshi Ichikawa, Yasuyuki Kimura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The mechanical properties of a micrometer-sized giant liposome are studied by deforming it from the inside using dual-beam optical tweezers. As the liposome is extended, its shape changes from a sphere to a lemon shape, and finally, a tubular part is generated. The surface tension σ and the bending rigidity κ of the lipid membrane are obtained from the measured force-extension curve. In a one-phase liposome, it was found that σ increases as the charged component increases but κ remains approximately constant. In a two-phase liposome, the characteristic deformation and the force-extension curve differ from those observed for the one-phase liposome.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalChemical Physics Letters
Issue number4-6
Publication statusPublished - Sept 17 2009

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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