TY - JOUR
T1 - Mecamylamine-precipitated nicotine-withdrawal aversion in rats
AU - Suzuki, Tsutomu
AU - Ise, Yuya
AU - Tsuda, Makoto
AU - Maeda, Jun
AU - Misawa, Miwa
PY - 1996/10/31
Y1 - 1996/10/31
N2 - The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.
AB - The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.
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U2 - 10.1016/S0014-2999(96)00723-6
DO - 10.1016/S0014-2999(96)00723-6
M3 - Article
C2 - 8957247
AN - SCOPUS:0030608344
SN - 0014-2999
VL - 314
SP - 281
EP - 284
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -