Mecamylamine-precipitated nicotine-withdrawal aversion in rats

Tsutomu Suzuki, Yuya Ise, Makoto Tsuda, Jun Maeda, Miwa Misawa

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87 Citations (Scopus)


The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished - Oct 31 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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