Matrix Protein Interactions with Synthetic Surfaces

Patricia Rico, Marco Cantini, George Altankov, Manuel Salmerón-Sánchez

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)


Based on the hypothesis that material substrates are able to trigger the regeneration of a cell population by making use of tissue engineering techniques. Within the context of the cell-protein-material interaction paradigm, this chapter presents a comprehensive description of the interface between material surfaces and living cells, including protein adsorption, cell adhesion, and matrix remodeling phenomena at the cell-material interface. Cell adhesion involves different physicochemical phenomena, in which several biological molecules participate: extracellular matrix (ECM) proteins, cell membrane proteins, and cytoskeleton proteins. The initial cell-material interaction usually involves the adsorption of proteins such as fibronectin (FN), vitronectin (VN), fibrinogen (FG), representing the so-called soluble matrix proteins in the biological fluids. The adsorption of proteins onto the surface of a biomaterial from the surrounding fluid phase is a complex, dynamic, energy-driven process, controlled by protein properties, material surface properties, and solution conditions.

Original languageEnglish
Title of host publicationPolymers in Regenerative Medicine
Subtitle of host publicationBiomedical Applications from Nano- to Macro-Structures
Number of pages56
ISBN (Electronic)9781118356692
ISBN (Print)9780470596388
Publication statusPublished - Jan 30 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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