Materials chemistry of triplet dynamic nuclear polarization

Koki Nishimura; Hironori Kouno; Yusuke Kawashima; Kana Orihashi; Saiya Fujiwara; Kenichiro Tateishi; Tomohiro Uesaka; Nobuo Kimizuka; Nobuhiro Yanai

doi:10.1039/d0cc02258f

Materials chemistry of triplet dynamic nuclear polarization

Koki Nishimura, Hironori Kouno, Yusuke Kawashima, Kana Orihashi, Saiya Fujiwara, Kenichiro Tateishi, Tomohiro Uesaka, Nobuo Kimizuka, Nobuhiro Yanai

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at a moderate temperature. While many efforts have been devoted to achieving a large nuclear polarization based on triplet-DNP, the application of triplet-DNP has been limited to nuclear physics experiments. The recent introduction of materials chemistry into the field of triplet-DNP has achieved air-stable and water-soluble polarizing agents as well as the hyperpolarization of nanomaterials with a large surface area such as nanoporous metal-organic frameworks (MOFs) and nanocrystal dispersion in water. This Feature Article overviews the recently-emerged materials chemistry of triplet-DNP that paves new paths towards unprecedented biological and medical applications.

Original language	English
Pages (from-to)	7217-7232
Number of pages	16
Journal	Chemical Communications
Volume	56
Issue number	53
DOIs	https://doi.org/10.1039/d0cc02258f
Publication status	Published - Jul 7 2020

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Materials chemistry of triplet dynamic nuclear polarization",

abstract = "Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at a moderate temperature. While many efforts have been devoted to achieving a large nuclear polarization based on triplet-DNP, the application of triplet-DNP has been limited to nuclear physics experiments. The recent introduction of materials chemistry into the field of triplet-DNP has achieved air-stable and water-soluble polarizing agents as well as the hyperpolarization of nanomaterials with a large surface area such as nanoporous metal-organic frameworks (MOFs) and nanocrystal dispersion in water. This Feature Article overviews the recently-emerged materials chemistry of triplet-DNP that paves new paths towards unprecedented biological and medical applications.",

author = "Koki Nishimura and Hironori Kouno and Yusuke Kawashima and Kana Orihashi and Saiya Fujiwara and Kenichiro Tateishi and Tomohiro Uesaka and Nobuo Kimizuka and Nobuhiro Yanai",

note = "Funding Information: This work was partly supported by the JST-PRESTO program on {\textquoteleft}{\textquoteleft}Creation of Life Science Basis by Using Quantum Technology{\textquoteright}{\textquoteright} (grant number: JPMJPR18GB), JSPS KAKENHI (grant numbers: JP17H04799, JP16H06513, and JP17J04506), the Nakatani Foundation, the Shinnihon Foundation of Advanced Medical Treatment Research, the RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), and the RIKEN Pioneering Project {\textquoteleft}{\textquoteleft}Dynamic Structural Biology{\textquoteright}{\textquoteright}. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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doi = "10.1039/d0cc02258f",

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AU - Nishimura, Koki

AU - Kouno, Hironori

AU - Kawashima, Yusuke

AU - Orihashi, Kana

AU - Fujiwara, Saiya

AU - Tateishi, Kenichiro

AU - Uesaka, Tomohiro

AU - Kimizuka, Nobuo

AU - Yanai, Nobuhiro

N1 - Funding Information: This work was partly supported by the JST-PRESTO program on ‘‘Creation of Life Science Basis by Using Quantum Technology’’ (grant number: JPMJPR18GB), JSPS KAKENHI (grant numbers: JP17H04799, JP16H06513, and JP17J04506), the Nakatani Foundation, the Shinnihon Foundation of Advanced Medical Treatment Research, the RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), and the RIKEN Pioneering Project ‘‘Dynamic Structural Biology’’. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/7/7

Y1 - 2020/7/7

N2 - Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at a moderate temperature. While many efforts have been devoted to achieving a large nuclear polarization based on triplet-DNP, the application of triplet-DNP has been limited to nuclear physics experiments. The recent introduction of materials chemistry into the field of triplet-DNP has achieved air-stable and water-soluble polarizing agents as well as the hyperpolarization of nanomaterials with a large surface area such as nanoporous metal-organic frameworks (MOFs) and nanocrystal dispersion in water. This Feature Article overviews the recently-emerged materials chemistry of triplet-DNP that paves new paths towards unprecedented biological and medical applications.

AB - Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at a moderate temperature. While many efforts have been devoted to achieving a large nuclear polarization based on triplet-DNP, the application of triplet-DNP has been limited to nuclear physics experiments. The recent introduction of materials chemistry into the field of triplet-DNP has achieved air-stable and water-soluble polarizing agents as well as the hyperpolarization of nanomaterials with a large surface area such as nanoporous metal-organic frameworks (MOFs) and nanocrystal dispersion in water. This Feature Article overviews the recently-emerged materials chemistry of triplet-DNP that paves new paths towards unprecedented biological and medical applications.

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Materials chemistry of triplet dynamic nuclear polarization

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