Marked discreteness on the coil-globule transition of single duplex DNA

K. Yoshikawa, S. Kidoaki, M. Takahashi, V. V. Vasitevskaya, A. R. Khokhlov

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


From the study of single molecular observation of individual DNA chains by use of fluorescence microscopy, it has become clear that the transition between elongated coil state and compacted globule state is highly discrete on the level of individual chains. On the other hand, the transition appears continuous on the level of the ensemble of DNAs. We report the experimental evidence on this unique property of the DNA chain, using T4 DNA, 166 kilo base pairs (kbp), with the addition of Co{NH3)63+. Theoretical consideration has beer, performed on the bimodality in the free energy of single DNA chains, indicating that the character of the coil-globule transition changes largely depending on the valency of the coexistence cationic species.

Original languageEnglish
Pages (from-to)876-880
Number of pages5
JournalBerichte der Bunsengesellschaft/Physical Chemistry Chemical Physics
Issue number6
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering


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