TY - JOUR
T1 - Mammalian cell mutants of membrane phlospholipid biogenesis
AU - Nishijima, Masahiro
AU - Kuge, Osamu
AU - Hanada, Kentaro
N1 - Funding Information:
We are grateful to Yuzuru Akamatsu for his continuous encouragement these studies. This work was supported in part by Grants-in-Aid for General Scientific Research from the Ministry of Education, Science and Culture of Japan, by the Integrated Study Projects of the Japan Health Sciences Foundation and by research grants from the Naito Foundation, the TERM0 Science Foundation and the Mochida Memorial Foundation. We apologize to those whose work was not discussed or cited directly because of space limitations.
PY - 1997/8
Y1 - 1997/8
N2 - Cultured mammalian cell mutants defective in the biosynthesis of membrane phospholipids, although limited in number, are increasing our understanding of the molecular mechanisms underlying the biogenesis and the biological significance of membrane phospholipids in higher eukaryotes. This review summarizes the progress in the isolation and characterization of such mutants, focusing on those isolated from cultured Chinese hamster ovary (CHO) cells.
AB - Cultured mammalian cell mutants defective in the biosynthesis of membrane phospholipids, although limited in number, are increasing our understanding of the molecular mechanisms underlying the biogenesis and the biological significance of membrane phospholipids in higher eukaryotes. This review summarizes the progress in the isolation and characterization of such mutants, focusing on those isolated from cultured Chinese hamster ovary (CHO) cells.
UR - http://www.scopus.com/inward/record.url?scp=0030807664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030807664&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(97)01084-2
DO - 10.1016/S0962-8924(97)01084-2
M3 - Review article
C2 - 17708968
AN - SCOPUS:0030807664
SN - 0962-8924
VL - 7
SP - 324
EP - 329
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -