Abstract
We encountered a 65-year-old woman with diffuse large B-cell lymphoma showing t(8;14)(q24;q32) and c-myc gene rearrangement that developed following 12 years of melphalan-based chemotherapy for multiple myeloma. Short-term remission was obtained by CHOP chemotherapy. However, shortly thereafter the patient died of an aggressive progression of lymphoma. It was suspected that the lymphoma was a secondary malignancy related to the treatment with cytotoxic agents and radiation for prolonged multiple myeloma. The chromosomal abnormality t(8;14)(q24;q32) is rare in secondary malignancies. Overexpression of c-myc by gene rearrangement may be associated with clinical courses manifested by the rapid progression of lymphoma.
| Original language | English |
|---|---|
| Pages (from-to) | 1265-1270 |
| Number of pages | 6 |
| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| Volume | 40 |
| Issue number | 12 |
| Publication status | Published - Dec 1999 |
All Science Journal Classification (ASJC) codes
- Medicine(all)