Magnetic nanoparticle imaging using cooled pickup coil and harmonic signal detection

Keiji Enpuku, Takafumi Morishige, Takuro Mihaya, Takashi Miyazai, Masaaki Matsuo, Seki Haku, Takashi Yoshida

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We developed a highly sensitive measurement system using a Cu pickup coil cooled at 77 K for magnetic nanoparticle imaging. The magnetic field noise of the system was as low as 90 fT/Hz1/2 at the resonant frequency of 3 kHz when the pickup coil was connected to a resonant capacitor. We also characterized the magnetic properties of the nanoparticles for use in magnetic nanoparticle imaging. We demonstrated the detection of nanoparticles using the third-harmonic signal generated by the nonlinear magnetization of nanoparticles. An excitation field having a frequency of 1 kHz and amplitude of 1.6mT was applied to the magnetic particles, and the third harmonic signal at 3 kHz was detected. By separating the signal frequency from that of the excitation field, we could avoid the interference of the excitation field and were able to obtain a clear contour map of the signal field. We could detect 100 μg of magnetic nanoparticles located as far as 100mm under the pickup coil.

Original languageEnglish
Article number087001
JournalJapanese journal of applied physics
Issue number8
Publication statusPublished - Aug 2013

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Physics and Astronomy


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