Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

Takuya Kubo; Kaname Tachibana; Toyohiro Naito; Sadaatsu Mukai; Kazunari Akiyoshi; Jeyadevan Balachandran; Koji Otsuka

doi:10.1021/acsbiomaterials.8b01401

Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

Takuya Kubo, Kaname Tachibana, Toyohiro Naito, Sadaatsu Mukai, Kazunari Akiyoshi, Jeyadevan Balachandran, Koji Otsuka

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A new stimulus-responsive drug delivery system using Fe ₃ O ₄ nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

Original language	English
Pages (from-to)	759-767
Number of pages	9
Journal	ACS Biomaterials Science and Engineering
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acsbiomaterials.8b01401
Publication status	Published - Feb 11 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

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10.1021/acsbiomaterials.8b01401

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title = "Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer",

abstract = " A new stimulus-responsive drug delivery system using Fe 3 O 4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.",

author = "Takuya Kubo and Kaname Tachibana and Toyohiro Naito and Sadaatsu Mukai and Kazunari Akiyoshi and Jeyadevan Balachandran and Koji Otsuka",

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T1 - Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

AU - Kubo, Takuya

AU - Tachibana, Kaname

AU - Naito, Toyohiro

AU - Mukai, Sadaatsu

AU - Akiyoshi, Kazunari

AU - Balachandran, Jeyadevan

AU - Otsuka, Koji

PY - 2019/2/11

Y1 - 2019/2/11

N2 - A new stimulus-responsive drug delivery system using Fe 3 O 4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

AB - A new stimulus-responsive drug delivery system using Fe 3 O 4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

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Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

Abstract

All Science Journal Classification (ASJC) codes

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