TY - JOUR
T1 - Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel
AU - Teramoto, Takayuki
AU - Sternick, Laura A.
AU - Kage-Nakadai, Eriko
AU - Sajjadi, Shirine
AU - Siembida, Jakub
AU - Mitani, Shohei
AU - Iwasaki, Kouichi
AU - Lambie, Eric J.
PY - 2010/3/8
Y1 - 2010/3/8
N2 - Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.
AB - Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.
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U2 - 10.1371/journal.pone.0009589
DO - 10.1371/journal.pone.0009589
M3 - Article
C2 - 20221407
AN - SCOPUS:77949733290
SN - 1932-6203
VL - 5
JO - PloS one
JF - PloS one
IS - 3
M1 - e9589
ER -