MACC1 expression levels as a novel prognostic marker for colorectal cancer

Hirofumi Yamamoto; Norikatsu Miyoshi; Koshi Mimori; Toshiki Hitora; Masayoshi Tokuoka; Shiki Fujino; Haley L. Ellis; Hideshi Ishii; Shingo Noura; Masayuki Ohue; Masahiko Yano; Yuichiro Doki; Masaki Mori

doi:10.3892/ol.2014.2460

MACC1 expression levels as a novel prognostic marker for colorectal cancer

Hirofumi Yamamoto, Norikatsu Miyoshi, Koshi Mimori, Toshiki Hitora, Masayoshi Tokuoka, Shiki Fujino, Haley L. Ellis, Hideshi Ishii, Shingo Noura, Masayuki Ohue, Masahiko Yano, Yuichiro Doki, Masaki Mori

Surgery

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients.

Original language	English
Pages (from-to)	2305-2309
Number of pages	5
Journal	Oncology Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.3892/ol.2014.2460
Publication status	Published - Nov 1 2014

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ol.2014.2460

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title = "MACC1 expression levels as a novel prognostic marker for colorectal cancer",

abstract = "Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients.",

author = "Hirofumi Yamamoto and Norikatsu Miyoshi and Koshi Mimori and Toshiki Hitora and Masayoshi Tokuoka and Shiki Fujino and Ellis, {Haley L.} and Hideshi Ishii and Shingo Noura and Masayuki Ohue and Masahiko Yano and Yuichiro Doki and Masaki Mori",

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T1 - MACC1 expression levels as a novel prognostic marker for colorectal cancer

AU - Yamamoto, Hirofumi

AU - Miyoshi, Norikatsu

AU - Mimori, Koshi

AU - Hitora, Toshiki

AU - Tokuoka, Masayoshi

AU - Fujino, Shiki

AU - Ellis, Haley L.

AU - Ishii, Hideshi

AU - Noura, Shingo

AU - Ohue, Masayuki

AU - Yano, Masahiko

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients.

AB - Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients.

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JO - Oncology Letters

JF - Oncology Letters

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ER -

MACC1 expression levels as a novel prognostic marker for colorectal cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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