Lymphoid progenitors and primary routes to becoming cells of the immune system

Rosana Pelayo, Rob Welner, S. Scott Perry, Jiaxue Huang, Yoshihiro Baba, Takafumi Yokota, Paul W. Kincade

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)


Extraordinary progress has been made in charting the maturation of hematopoietic cells. However, these charted processes do not necessarily represent obligate pathways to specialized types of lymphocytes. In fact, there is a degree of plasticity associated with primitive progenitors. Moreover, all lymphocytes of a given kind are not necessarily produced through precisely the same sequence of events. Particularly contentious is the nature of cells that seed the thymus, because different progenitors can generate T cells under experimental circumstances. Non-renewing progenitors with a high density of c-Kit in bone marrow are likely to replenish the thymus under normal circumstances and most closely resemble canonical T cell progenitors.

Original languageEnglish
Pages (from-to)100-107
Number of pages8
JournalCurrent Opinion in Immunology
Issue number2
Publication statusPublished - Apr 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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