TY - GEN
T1 - Lymphoid lineage fate decision of hematopoietic stem cells
AU - Akashi, Koichi
PY - 2009
Y1 - 2009
N2 - To understand the mechanism in lymphoid development, it is critical to identify developmental intermediates downstream of hematopoietic stem cells, including cells responsible for seeding the thymus. Although early studies showed that hematopoietic stem cells choose either the myeloid-erythroid or the lymphoid pathway, recent data suggest that myelo-lymphoid precursors lacking erythroid potential exist in early hematopoiesis before cells are fully committed to the lymphoid lineage. We here summarize the phenotype and functional properties of such progenitors and the current developmental map for the lymphoid lineage.
AB - To understand the mechanism in lymphoid development, it is critical to identify developmental intermediates downstream of hematopoietic stem cells, including cells responsible for seeding the thymus. Although early studies showed that hematopoietic stem cells choose either the myeloid-erythroid or the lymphoid pathway, recent data suggest that myelo-lymphoid precursors lacking erythroid potential exist in early hematopoiesis before cells are fully committed to the lymphoid lineage. We here summarize the phenotype and functional properties of such progenitors and the current developmental map for the lymphoid lineage.
UR - http://www.scopus.com/inward/record.url?scp=70349836512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349836512&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04570.x
DO - 10.1111/j.1749-6632.2009.04570.x
M3 - Conference contribution
C2 - 19796229
AN - SCOPUS:70349836512
SN - 9781573317610
T3 - Annals of the New York Academy of Sciences
SP - 18
EP - 25
BT - Hematopoietic Stem Cells VII
PB - Blackwell Publishing Inc.
ER -