Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Lu Lu Wang, Li Jun Hao, Zhong Bo Zhou, Xin Liu Zhu, Ze Hui Shi, Tomofumi Miyamoto, Ke Pan

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Thirteen previously undescribed lycodine-type Lycopodium alkaloids, namely, five alkaloids (lycocasuarines D–H) each possessing an uncommon five-membered C ring and eight Lycopodium alkaloid glycosides (casuarinosides A–H), together with a known analog, were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit (Lycopodiaceae). The structures of the compounds were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical methods. In addition, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.

Original languageEnglish
Pages (from-to)63-72
Number of pages10
Publication statusPublished - Oct 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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