Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Lu Lu Wang; Li Jun Hao; Zhong Bo Zhou; Xin Liu Zhu; Ze Hui Shi; Tomofumi Miyamoto; Ke Pan

doi:10.1016/j.phytochem.2018.06.016

Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Lu Lu Wang, Li Jun Hao, Zhong Bo Zhou, Xin Liu Zhu, Ze Hui Shi, Tomofumi Miyamoto, Ke Pan

Pharmaceutical Health Care and Sciences

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20 Citations (Scopus)

Abstract

Thirteen previously undescribed lycodine-type Lycopodium alkaloids, namely, five alkaloids (lycocasuarines D–H) each possessing an uncommon five-membered C ring and eight Lycopodium alkaloid glycosides (casuarinosides A–H), together with a known analog, were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit (Lycopodiaceae). The structures of the compounds were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical methods. In addition, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Phytochemistry
Volume	154
DOIs	https://doi.org/10.1016/j.phytochem.2018.06.016
Publication status	Published - Oct 2018

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2018.06.016

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title = "Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides",

abstract = "Thirteen previously undescribed lycodine-type Lycopodium alkaloids, namely, five alkaloids (lycocasuarines D–H) each possessing an uncommon five-membered C ring and eight Lycopodium alkaloid glycosides (casuarinosides A–H), together with a known analog, were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit (Lycopodiaceae). The structures of the compounds were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical methods. In addition, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.",

author = "Wang, {Lu Lu} and Hao, {Li Jun} and Zhou, {Zhong Bo} and Zhu, {Xin Liu} and Shi, {Ze Hui} and Tomofumi Miyamoto and Ke Pan",

note = "Funding Information: The authors thank the National Natural Science Foundation of China (No. 81403083 ) for providing financial support for this work. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = oct,

doi = "10.1016/j.phytochem.2018.06.016",

language = "English",

volume = "154",

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journal = "Phytochemistry",

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T1 - Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

AU - Wang, Lu Lu

AU - Hao, Li Jun

AU - Zhou, Zhong Bo

AU - Zhu, Xin Liu

AU - Shi, Ze Hui

AU - Miyamoto, Tomofumi

AU - Pan, Ke

PY - 2018/10

Y1 - 2018/10

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AB - Thirteen previously undescribed lycodine-type Lycopodium alkaloids, namely, five alkaloids (lycocasuarines D–H) each possessing an uncommon five-membered C ring and eight Lycopodium alkaloid glycosides (casuarinosides A–H), together with a known analog, were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit (Lycopodiaceae). The structures of the compounds were elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical methods. In addition, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.

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JO - Phytochemistry

JF - Phytochemistry

ER -

Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Abstract

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