TY - JOUR
T1 - Lycium schweinfurthii
T2 - new secondary metabolites and their cytotoxic activities
AU - Elbermawi, Ahmed
AU - Halim, Ahmed F.
AU - Mansour, El Sayed S.
AU - Ahmad, Kadria F.
AU - Elsbaey, Marwa
AU - Ashour, Ahmed
AU - Amen, Yhiya
AU - El-Gamil, Mohammed M.
AU - Tomofumi, Miyamoto
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
Gratefully, the first author acknowledges the ministry of higher education, Egypt for scholarship support.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines. Certain flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates.
AB - Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines. Certain flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates.
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U2 - 10.1080/14786419.2021.1922902
DO - 10.1080/14786419.2021.1922902
M3 - Article
C2 - 34180314
AN - SCOPUS:85117430652
SN - 1478-6419
VL - 36
SP - 5134
EP - 5141
JO - Natural Product Research
JF - Natural Product Research
IS - 20
ER -
