TY - JOUR
T1 - Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images
AU - Sonoda, Shozo
AU - Sakamoto, Taiji
AU - Yamashita, Takehiro
AU - Uchino, Eisuke
AU - Kawano, Hiroki
AU - Yoshihara, Naoya
AU - Terasaki, Hiroto
AU - Shirasawa, Makoto
AU - Tomita, Masatoshi
AU - Ishibashi, Tatsuro
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Financial disclosures: Taiji Sakamoto: (consultant) Bausch and Lomb; (consultant and grant funding) Wakamoto Co, Ltd; (consultant) Bayer Japan; (consultant, grant funding, lecture fee, and meeting expenses) Novartis, K.K.; (grant funding, lecture fee, and meeting expenses) Santen Pharm Co, Ltd; (grant funding, lecture fee, and meeting expenses) Senju Pharm Co, Ltd; (grant funding) Hoya Corp; (lecture fee and meeting expenses) Pfizer Japan, Inc; (grant funding, lecture fee, and meeting expenses) Kowa Co Ltd; (lecture fee and meeting expenses) Alcon Japan, Ltd; Tatsuro Ishibashi: (consultant) Bausch and Lomb; (consultant and grant funding) Wakamoto Co, Ltd; (grant funding, lecture fee, and meeting expenses) Novartis, K.K.; (grant funding, lecture fee, and meeting expenses) Santen Pharm Co, Ltd; (grant funding, lecture fee, and meeting expenses) Senju Pharm Co, Ltd; (grant funding) Hoya Corp; (grant funding, lecture fee, and meeting expenses) Pfizer Japan, Inc; (grant funding, lecture fee, and meeting expenses) Kowa Co Ltd; (lecture fee and meeting expenses) Alcon Japan, Ltd. Funding/support: The funding organizations had no role in the design or conduct of this research. This study was done under a grant from the Research Committee on Chorioretinal Degeneration and Optic Atrophy, Ministry of Health, Labor, and Welfare, Tokyo, Japan; and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of the Japanese Government, Tokyo, Japan. All authors attest that they meet the current ICMJE requirements to qualify as authors.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Purpose To determine the proportion of luminal and stromal areas of normal choroids in the optical coherence tomographic (OCT) images obtained by enhanced depth imaging (EDI)-OCT. Design A prospective, masked, observational cross-sectional study. Methods setting: This study was performed at the Kagoshima University Hospital, Japan. study population: One hundred and eighty right eyes of 180 healthy volunteers (106 women; mean age of 55.9 years) without ocular pathology. observational procedures: The EDI-OCT images of the posterior choroid 7500 μm from the optic disc in the horizontal plane were converted to binary images. The total cross-sectional choroidal area, luminal area, and stromal area of the choroid were measured. main outcome measures: Correlations between clinical factors and each choroidal structure and ratio of luminal/stromal areas were determined. The correlations of each choroidal structure and the age, sex, axial length (AL), and refractive errors were calculated. Results The mean total cross-sectional choroidal area was 1.84 mm2 (luminal area 1.21 mm2 and stromal area 0.63 mm2). Multivariate analysis (standardized partial regression coefficient) showed that age (-0.723, P <.001) was significantly correlated with the reduced area of the choroid, and the correlation was greater than that for the AL (-0.408, P <.001). The ratio of luminal/stromal area was significantly reduced in eyes with longer ALs (-0.531, P <.001), and the strength of the correlation was greater than that of age (-0.389, P <.001). Conclusions Although both the luminal and the stromal areas decrease with increasing age and with longer ALs, the degree of decrease and areas affected were not the same.
AB - Purpose To determine the proportion of luminal and stromal areas of normal choroids in the optical coherence tomographic (OCT) images obtained by enhanced depth imaging (EDI)-OCT. Design A prospective, masked, observational cross-sectional study. Methods setting: This study was performed at the Kagoshima University Hospital, Japan. study population: One hundred and eighty right eyes of 180 healthy volunteers (106 women; mean age of 55.9 years) without ocular pathology. observational procedures: The EDI-OCT images of the posterior choroid 7500 μm from the optic disc in the horizontal plane were converted to binary images. The total cross-sectional choroidal area, luminal area, and stromal area of the choroid were measured. main outcome measures: Correlations between clinical factors and each choroidal structure and ratio of luminal/stromal areas were determined. The correlations of each choroidal structure and the age, sex, axial length (AL), and refractive errors were calculated. Results The mean total cross-sectional choroidal area was 1.84 mm2 (luminal area 1.21 mm2 and stromal area 0.63 mm2). Multivariate analysis (standardized partial regression coefficient) showed that age (-0.723, P <.001) was significantly correlated with the reduced area of the choroid, and the correlation was greater than that for the AL (-0.408, P <.001). The ratio of luminal/stromal area was significantly reduced in eyes with longer ALs (-0.531, P <.001), and the strength of the correlation was greater than that of age (-0.389, P <.001). Conclusions Although both the luminal and the stromal areas decrease with increasing age and with longer ALs, the degree of decrease and areas affected were not the same.
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U2 - 10.1016/j.ajo.2015.03.005
DO - 10.1016/j.ajo.2015.03.005
M3 - Article
C2 - 25790737
AN - SCOPUS:84929129511
SN - 0002-9394
VL - 159
SP - 1123-1131.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -