Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

Takao Shimazoe; Miyuki Maetani; Sachiko Nakamura; Shiro Yamanouchi; Shigenori Watanabe; Kyoko Miyasaka; Akira Kono; Akihiro Funakoshi

doi:10.1254/jjp.80.85

Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

Takao Shimazoe, Miyuki Maetani, Sachiko Nakamura, Shiro Yamanouchi, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Japanese Journal of Pharmacology
Volume	80
Issue number	1
DOIs	https://doi.org/10.1254/jjp.80.85
Publication status	Published - 1999

All Science Journal Classification (ASJC) codes

Pharmacology

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title = "Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats",

abstract = "The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.",

author = "Takao Shimazoe and Miyuki Maetani and Sachiko Nakamura and Shiro Yamanouchi and Shigenori Watanabe and Kyoko Miyasaka and Akira Kono and Akihiro Funakoshi",

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doi = "10.1254/jjp.80.85",

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T1 - Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

AU - Shimazoe, Takao

AU - Maetani, Miyuki

AU - Nakamura, Sachiko

AU - Yamanouchi, Shiro

AU - Watanabe, Shigenori

AU - Miyasaka, Kyoko

AU - Kono, Akira

AU - Funakoshi, Akihiro

PY - 1999

Y1 - 1999

N2 - The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.

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Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

Abstract

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