Low protein diets posttranscriptionally repress apolipoprotein B expression in rat liver

Masao Sato, Koji Nagao, Masanobu Sakono, Hiroshi Ogawa, Kyosuke Yamamoto, Katsumi Imaizumi

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10 Citations (Scopus)


In an attempt to elucidate molecular mechanisms related to low protein diet-induced fatty livers, apolipoprotein (apo) mRNA and its expression in the liver were studied in rats. Rats were fed for 14 days a diet containing 5% and 20% casein, and whey protein equivalent in protein to these caseins. In the protein-deficient groups, liver triacylglycerols elevated to 1.5-2 fold higher than did the diet sufficient groups. The mRNAs for apo A-IV, apo B and apo E were 20 to 50% lower in the deficient groups than in the sufficient groups, but apo A-I mRNA was not reduced. The rate of transcription of apo A-IV, B, and E genes in hepatic nuclei isolated from those animals was not altered with different levels of dietary protein. Apo B concentration in the serum was lowered and correlated positively with apo B mRNA abundance but the concentrations of apo IV and apo E were elevated in the deficient groups. It thus appears that a low protein diet decreases apo B synthesis through a posttranscriptional mechanism and thereby depresses secretion of triacylglycerol-rich lipoproteins from the liver.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalJournal of Nutritional Biochemistry
Issue number7
Publication statusPublished - Jul 1996

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry


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