TY - JOUR
T1 - Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle
AU - Mitoma, Chikage
AU - Kohda, Futoshi
AU - Mizote, Yukihiro
AU - Miake, Akira
AU - Ijichi, Ayako
AU - Kawahara, Saho
AU - Kohno, Miki
AU - Sonoyama, Hiroko
AU - Mitamura, Yasutaka
AU - Kaku, Yumiko
AU - Inoue, Hiroko
AU - Sasaki, Yoshiko
AU - Ohno, Fumitaka
AU - Okabe, Noriko
AU - Take, Nobutoshi
AU - Mizote, Mika
AU - Masuda, Akiko
AU - Furue, Masutaka
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2014/7/1
Y1 - 2014/7/1
N2 - The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.
AB - The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.
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M3 - Article
C2 - 25417529
AN - SCOPUS:84925284533
SN - 0016-254X
VL - 105
SP - 148
EP - 156
JO - Fukuoka igaku zasshi = Hukuoka acta medica
JF - Fukuoka igaku zasshi = Hukuoka acta medica
IS - 7
ER -