Load dependence of ventricular performance explained by changes in calcium myofilament interactions

Juichiro Shimizu, Koji Todaka, Daniel Burkhoff

Research output: Contribution to journalConference articlepeer-review

Abstract

A study was carried out to test whether a 4-state biochemical model with length dependent rate constants could explain contractile behavior of ejecting hearts. Studies were performed in isolated, physiologically afterloaded canine hearts and intracellular calcium transients measured with macroinjected aequorin. Results help bridge the gap between basic molecular research and whole organ physiology.

Original languageEnglish
Pages (from-to)S-60
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
Publication statusPublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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