TY - JOUR
T1 - Liquid-phase detection of biological targets with magnetic marker and superconducting quantum interference device
AU - Enpuku, Keiji
AU - Sugimoto, Yuki
AU - Tamai, Yuya
AU - Tsukamoto, Akira
AU - Mizoguchi, Takako
AU - Kandori, Akihiko
AU - Usuki, Naoki
AU - Kanzaki, Hisao
AU - Yoshinaga, Kohji
AU - Sugiura, Yoshinori
AU - Kuma, Hiroyuki
AU - Hamasaki, Naotaka
PY - 2009
Y1 - 2009
N2 - Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotincoated polymer beads, IgE and Candida albicans.
AB - Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotincoated polymer beads, IgE and Candida albicans.
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U2 - 10.1587/transele.E92.C.315
DO - 10.1587/transele.E92.C.315
M3 - Article
AN - SCOPUS:77950426169
SN - 0916-8524
VL - E92-C
SP - 315
EP - 322
JO - IEICE Transactions on Electronics
JF - IEICE Transactions on Electronics
IS - 3
ER -