TY - JOUR
T1 - Liquid membrane operations in a microfluidic device for separation of metal ions
AU - Maruyama, Tatsuo
AU - Matsushita, Hironari
AU - Uchida, Jun Ichi
AU - Kubota, Fukiko
AU - Kamiya, Noriho
AU - Goto, Masahiro
PY - 2004/8/1
Y1 - 2004/8/1
N2 - A three-phase flow, water/n-heptane/water, was constructed in a microchannel (100-μm width, 25-μm depth) on a glass microchip (3 cm × 7 cm) and was used as a liquid membrane for separation of metal ions. Surface modification of the microchannel by octadecylsilane groups induced spontaneous phase separation of the three-phase flow in the microfluidic device, which allows control of interfacial contact time and off-chip analysis using conventional analytical apparatus. Prior to the selective transport of a metal ion through the liquid membrane in the microchannel, the forward and backward extraction of yttrium and zinc ions was investigated in a two-phase flow on a microfluidic device using 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (commercial name, PC-88A) as an extractant. The extraction conditions (contact time of the two phases, pH, extractant concentration) in the microfluidic device were examined. These investigations demonstrated that the conventional methodology for solvent extraction of metal ions is applicable to solvent extraction in a microchannel. Finally, we employed the three-phase flow in the microchannel as a liquid membrane and observed the selective transport of Y ion through the liquid membrane. In the present study, we succeeded, for the first time, in the selective separation of a targeted metal ion from an aqueous feed solution to a receiving phase within a few seconds by employing a liquid membrane formed in a microfluidic device.
AB - A three-phase flow, water/n-heptane/water, was constructed in a microchannel (100-μm width, 25-μm depth) on a glass microchip (3 cm × 7 cm) and was used as a liquid membrane for separation of metal ions. Surface modification of the microchannel by octadecylsilane groups induced spontaneous phase separation of the three-phase flow in the microfluidic device, which allows control of interfacial contact time and off-chip analysis using conventional analytical apparatus. Prior to the selective transport of a metal ion through the liquid membrane in the microchannel, the forward and backward extraction of yttrium and zinc ions was investigated in a two-phase flow on a microfluidic device using 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (commercial name, PC-88A) as an extractant. The extraction conditions (contact time of the two phases, pH, extractant concentration) in the microfluidic device were examined. These investigations demonstrated that the conventional methodology for solvent extraction of metal ions is applicable to solvent extraction in a microchannel. Finally, we employed the three-phase flow in the microchannel as a liquid membrane and observed the selective transport of Y ion through the liquid membrane. In the present study, we succeeded, for the first time, in the selective separation of a targeted metal ion from an aqueous feed solution to a receiving phase within a few seconds by employing a liquid membrane formed in a microfluidic device.
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U2 - 10.1021/ac049844h
DO - 10.1021/ac049844h
M3 - Article
C2 - 15283593
AN - SCOPUS:4143088056
SN - 0003-2700
VL - 76
SP - 4495
EP - 4500
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 15
ER -