LINEing germ and embryonic stem cells' silencing of retrotransposons

Takashi Ishiuchi, Maria Elena Torres-Padilla

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410-1428) and Castro-Diaz and colleagues (pp. 1397-1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals.

Original languageEnglish
Pages (from-to)1381-1383
Number of pages3
JournalGenes and Development
Issue number13
Publication statusPublished - Jul 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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