Linear mucosal defect may be characteristic of lansoprazole-associated collagenous colitis

Junji Umeno, Takayuki Matsumoto, Shotaro Nakamura, Yukihiko Jo, Shinichiro Yada, Katsuya Hirakawa, Ryuji Yoshimura, Hajime Yamagata, Tetsuji Kudo, Atsushi Hirano, Masaki Gushima, Takashi Yao, Yutaka Nakashima, Mitsuo Iida

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49 Citations (Scopus)


Background: Although some cases of collagenous colitis have been induced by lansoprazole (LPZ), the clinicopathologic features of LPZ-associated collagenous colitis have not been elucidated. Objective: To elucidate the clinical, endoscopic, and histopathologic features of LPZ-associated collagenous colitis. Design: Retrospective case study. Patients: The subjects were 13 patients with collagenous colitis diagnosed during a period from 2002 to 2007. Main Outcome Measurements: The colonoscopic and histopathologic findings were compared retrospectively between 9 cases of LPZ use (LPZ group) and 4 cases without the use of LPZ (non-LPZ group). Results: A colonoscopy revealed a linear mucosal defect more frequently in the LPZ group (7 of 9 cases [78%]) than in the non-LPZ group (0 of 4 cases [0%], P = .02). Friable mucosa was also noted in 4 patients (44%) in the LPZ group but none in the non-LPZ group. The colonoscopic finding in the non-LPZ group was either normal mucosa or nonspecific minimal abnormalities, whereas patients in the LPZ group had either a linear mucosal defect, mucosal bleeding, or both (P = .001). On histologic examination, the subepithelial collagen band was thicker in patients in the LPZ group than in those in the non-LPZ group (median 45 vs 26.3 μm). All patients in the LPZ group recovered from diarrhea after discontinuance of LPZ. Limitation: A small number of patients. Conclusions: Linear mucosal defects and friable mucosa may be characteristic colonoscopic findings in cases of LPZ-associated collagenous colitis.

Original languageEnglish
Pages (from-to)1185-1191
Number of pages7
JournalGastrointestinal endoscopy
Issue number7
Publication statusPublished - Jun 2008

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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