Ligand-inducible formation of RNA pseudoknot

Saki Matsumoto, Changfeng Hong, Takahiro Otabe, Asako Murata, Kazuhiko Nakatani

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.

Original languageEnglish
Pages (from-to)3539-3541
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number12
DOIs
Publication statusPublished - Jun 15 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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