Lifestyle-related diseases and an inter-organ metabolic network

Yasutaka Miyachi, Kyoichiro Tsuchiya, Yoshihiro Ogawa

Research output: Contribution to journalReview articlepeer-review


Lifestyle-related diseases such as type 2 diabetes, hypertension and dyslipidemia are a prominent cause of mortality in Japan, and there is a strong requirement for elucidation of detailed molecular mechanisms and effective therapeutic strategies. Obesity-induced adipose tissue inflammation leads to dysregulation of adipokine production, which can cause lifestyle-related diseases. The interaction of organ systems via endocrine or neural networks is recognized as an important factor in the pathogenesis and promotion of lifestyle-related diseases. Therefore, further investigation for the interaction between adipose tissues and bones can provide new treatment strategies of metabolic bone disorders.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalClinical calcium
Issue number3
Publication statusPublished - Mar 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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