Leser-Trélat sign with anaplastic ependymoma - An autopsy case

Yasuhiro Hamada, Toru Iwaki, Hiroshi Muratani, Shuhei Imayama, Masashi Fukui, Jun Tateishi

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9 Citations (Scopus)


A 36-year-old Japanese male, who 7 years previously had been diagnosed as having an ependymoma in the left parietal region, had received surgery, chemotherapy and radiotherapy. He later developed a rapid growth of multiple skin lesions on his back and extremities, which coincided with a regrowth of the tumor. Post-mortem examination revealed that the ependymoma showed anaplastic transformation and necrosis; however, no malignancy was observed in the extracranial organs. The skin lesions were histologically diagnosed as seborrheic keratoses. We have, therefore, diagnosed the patient as having Leser-Trélat sign associated with anaplastic ependymoma.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalActa neuropathologica
Issue number1
Publication statusPublished - Dec 1996

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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