Leptin Receptor

K. Takaya, Y. Ogawa, H. Masuzaki, N. Matsuoka, K. Hosoda, K. Nakao

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus. Ob-R is a member of cytokine receptors and involves the JAK-STAT signal transduction system. We found Ob-R mutations in Zucker fatty rats and obese Koletsky rats and demonstrated that Ob-R dysfunction brings around hyperphagia and obesity. However we and others have not found any Ob-R mutation in human obese subjects.

Original languageEnglish
Pages (from-to)1925-1930
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number7
Publication statusPublished - Jul 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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