TY - JOUR
T1 - Leptin inhibits stress-induced apoptosis of T lymphocytes
AU - Fujita, Y.
AU - Murakami, M.
AU - Ogawa, Y.
AU - Masuzaki, H.
AU - Tanaka, M.
AU - Ozaki, S.
AU - Nakao, K.
AU - Mimori, T.
PY - 2002
Y1 - 2002
N2 - Leptin, which is secreted by adipocytes, the placenta and the stomach, not only controls appetite through leptin receptors in the hypothalamus but also regulates cell-mediated immunity. In this study we have demonstrated that continuous injection of leptin prevents the reduction in lymphocyte numbers normally observed in fasted and steroid-injected mice. Consistent with leptin-induced protection, we observed up-regulation of the bcl-xL gene as a result of signal transduction via leptin receptors on lymphocytes. We suggest that leptin might contribute to the recovery of immune suppression in malnourished mice by inhibiting lymphocyte apoptosis.
AB - Leptin, which is secreted by adipocytes, the placenta and the stomach, not only controls appetite through leptin receptors in the hypothalamus but also regulates cell-mediated immunity. In this study we have demonstrated that continuous injection of leptin prevents the reduction in lymphocyte numbers normally observed in fasted and steroid-injected mice. Consistent with leptin-induced protection, we observed up-regulation of the bcl-xL gene as a result of signal transduction via leptin receptors on lymphocytes. We suggest that leptin might contribute to the recovery of immune suppression in malnourished mice by inhibiting lymphocyte apoptosis.
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U2 - 10.1046/j.1365-2249.2002.01797.x
DO - 10.1046/j.1365-2249.2002.01797.x
M3 - Article
C2 - 11982586
AN - SCOPUS:0036243107
SN - 0009-9104
VL - 128
SP - 21
EP - 26
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 1
ER -
