Learning from b12 enzymes: Biomimetic and bioinspired catalysts for eco-friendly organic synthesis

Keishiro Tahara, Ling Pan, Toshikazu Ono, Yoshio Hisaeda

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Cobalamins (B12) play various important roles in vivo. Most B12-dependent enzymes are divided into three main subfamilies: adenosylcobalamin-dependent isomerases, methylcobalamin-dependent methyltransferases, and dehalogenases. Mimicking these B12 enzyme functions under non-enzymatic conditions offers good understanding of their elaborate reaction mechanisms. Furthermore, bio-inspiration offers a new approach to catalytic design for green and eco-friendly molecular transformations. As part of a study based on vitamin B12 derivatives including heptamethyl cobyrinate perchlorate, we describe biomimetic and bioinspired catalytic reactions with B12 enzyme functions. The reactions are classified according to the corresponding three B12 enzyme subfamilies, with a focus on our recent development on electrochemical and photochemical catalytic systems. Other important reactions are also described, with a focus on radical-involved reactions in terms of organic synthesis.

Original languageEnglish
Pages (from-to)2553-2567
Number of pages15
JournalBeilstein Journal of Organic Chemistry
Publication statusPublished - Oct 2 2018

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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