TY - JOUR
T1 - Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat
AU - Yoshimatsu, Hironobu
AU - Niijima, Akira
AU - Oomura, Yutaka
AU - Katafuchi, Toshihiko
N1 - Funding Information:
We thank Dr. G. A. Bray (University of Southern California) for his help in preparing this manuscript. This study was supported by Ministry of Education, Sciences and Culture Grants (Y.O.) 57440085, 60440097 and 58870118.
PY - 1988/8
Y1 - 1988/8
N2 - Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.
AB - Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0024162601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024162601&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(88)90237-7
DO - 10.1016/0361-9230(88)90237-7
M3 - Article
C2 - 3191410
AN - SCOPUS:0024162601
SN - 0361-9230
VL - 21
SP - 239
EP - 244
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 2
ER -