Late T cell–mediated rejection may contribute to poor outcomes in adolescents and young adults with liver transplantation

Masahiro Takeda, Seisuke Sakamoto, Rie Irie, Hajime Uchida, Seiichi Shimizu, Yusuke Yanagi, Mohamed Sami Abdelwahed, Akinari Fukuda, Mureo Kasahara

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1 Citation (Scopus)


Although poor long-term graft survival in LT in AYA is recognized, detailed epidemiological data are still lacking. L-TCMR may have poor outcomes. This study aimed to provide a detailed, epidemiological assessment of the association between AYA age and rejection. L-TCMR was defined in this study as TCMR with central vein or perivenular inflammation occurring later than 3 months after LT. A total of 342 patients who survived for at least 3 months after LT between 2005 and 2015 were enrolled. The AYA group (10-24 years) was compared with the C group (less than 10 years), and the incidence and outcomes of L-TCMR were analyzed. In total, 342 patients had LT; 38 of these were AYA with the mean follow-up period of 6.7 years. A total of 304 patients in C group had a mean follow-up period of 6.3 years (P =.28). The incidence of L-TCMR in AYA group was significantly higher than in C group (15.8% vs 4.6%, P =.006). The time to L-TCMR after LT was significantly shorter in AYA group (P =.01). Neither patient survival nor the incidence of non-adherence differed significantly between the groups (P =.18 and P =.89). The number of additional immunosuppressants after L-TCMR was significantly higher in the AYA group (P =.04). A high incidence of L-TCMR was observed in AYA group irrespective of non-adherence. AYA patients with L-TCMR should be followed carefully due to the poor results of post-treatment biopsy and the need for intensive immunosuppressive therapy.

Original languageEnglish
Article numbere13708
JournalPediatric Transplantation
Issue number4
Publication statusPublished - Jun 1 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation


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