Laryngeal preservation with difinitive radiotherapy in radiosensitive hypopharyngeal cancer

Kunitake Naonobu, Nakamura Katsumasa, Shioyama Yoshiyuki, Kuratomi Yuichiro, Yamamoto Tomoya, Terashima Hiromi, Honda Hiroshi

    Research output: Contribution to journalArticlepeer-review


    Fifty-seven patients with hypopharyngeal cancer treated by irradiation at Kyushu University Hospital between 1985 and 1992 were analyzed retrospectively. They included 53 men and 4 women, and their ages ranged from 39 to 83 years (mean, 63 years). Two patients had stage I, 7 had stage II, 13 had stage III, and 35 had stage IV disease according to the UICC (1997) classification. Initially, they were irradiated in the conventional way with a dose of 30 Gy, and 17 patients with good response were irradiated to curative dose (more than 60 Gy), and 32 patients with poor response were operated immediately. Medically inoperable or unresectable patients were treated in a semiradical way (n=8). The 5-year overall and cause-specific survival rates were 46 % and 51 %, respectively. Five-year cause-specific survival rates were 88 % for stages I and II (n=9), 67 % for stage III (n=13), and 35 % for stage IV (n=35). Five-year cause-specific survival according to treatment method was 58 % for surgery and 51 % for curative radiotherapy. There was no statistically significant difference between the two rates. These results suggest that initial radiation response is an important factor in deciding on the following treatment method. Curative radiotherapy for hypopharyngeal cancer according to initial radiation response is a desirable treatment strategy.

    Original languageEnglish
    Pages (from-to)570-573
    Number of pages4
    JournalNippon Acta Radiologica
    Issue number9
    Publication statusPublished - Nov 25 2003

    All Science Journal Classification (ASJC) codes

    • Radiology Nuclear Medicine and imaging
    • Oncology


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