Large cell neuroendocrine carcinoma of the mediastinum with α-fetoprotein production

Ken Takezawa, Isamu Okamoto, Junya Fukuoka, Kaoru Tanaka, Hiroyasu Kaneda, Hisao Uejima, Hyung Eun Yoon, Masami Imakita, Masahiro Fukuoka, Kazuhiko Nakagawa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Large cell neuroendocrine carcinoma (LCNEC) is a relatively new category of pulmonary neuroendocrine tumor. Although it was first detected in the lung, LCNEC has since been found in a variety of extrapulmonary sites. We now describe a patient who was diagnosed with LCNEC originating from the mediastinum, an extremely rare disorder. An increased serum concentration of α-fetoprotein (AFP) in the patient was reduced by chemotherapy in association with tumor shrinkage. Furthermore, the tumor was confirmed immunohistochemically to produce AFP. To our knowledge, this is the first report of a LCNEC that produces AFP.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalJournal of Thoracic Oncology
Issue number2
Publication statusPublished - Feb 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine


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