Laparoscopic resection of a huge gastric gastrointestinal stromal tumor after neoadjuvant chemotherapy - A case report

Kota Kawabata, Tsuyoshi Takahashi, Kiyokazu Nakajima, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Masaki Mori, Yuichiro Doki

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2 Citations (Scopus)


An 83-year-old woman was hospitalized with abdominal discomfort. Abdominal computed tomography (CT) revealed a huge tumor (size, 15 cm) in the gastric body. Based on the findings of endoscopic ultrasonography-guided fine-needle aspiration, she was diagnosed with gastrointestinal stromal tumor (GIST). Invasion of the surrounding viscera and distant metastasis were not observed; however, owing to the tumor size (>10cm), we initiated neoadjuvant chemotherapy with imatinib. CT performed a month after chemotherapy revealed tumor shrinkage, and CT repeated 6 months after the second CT revealed tumor shrinkage to 8 cm. The patient showed a partial response to chemotherapy. She was deemed suitable to undergo laparoscopic radical resection and subsequently underwent laparoscopic partial gastric resection. Histopathological examination of the resected specimen (measuring 10 cm) revealed hyaline degeneration in most tumor cells and positive c-kit expression in only some proportion of tumor cells. Based on histopathological evaluation, the tumor was diagnosed as Grade 2b. The patient showed an uneventful postoperative course. After discharge, she received imatinib as adjuvant chemotherapy and is progressing well without recurrence. Taken together, we reported the case of a huge gastric GIST in a patient who showed significant tumor shrinkage following preoperative neoadjuvant chemotherapy and successfully underwent laparoscopic radical resection.

Original languageEnglish
Pages (from-to)670-672
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number4
Publication statusPublished - Apr 2020

All Science Journal Classification (ASJC) codes

  • General Medicine


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