Lantibiotics: Insight and foresight for new paradigm

Jun ichi Nagao, Sikder M. Asaduzzaman, Yuji Aso, Ken ichi Okuda, Jiro Nakayama, Kenji Sonomoto

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Lantibiotics are a unique type of antimicrobial peptide produced by a large number of gram-positive bacteria that contain unusual amino acids, such as lanthionine and dehydrated amino acids. Ribosomally synthesized lantibiotic prepeptide consists of an N-terminal leader peptide followed by a C-terminal propeptide moiety that undergoes several post-translational modification events to yield a biologically active lantibiotic. Research on lantibiotics has drawn much attention in recent years and has undergone extensive progress as a step forward to the next paradigm. Unusual amino acids in lantibiotics solely contribute to their biological activity and also enhance their structural stability. Thus, enzymes involved in lantibiotic biosynthesis would have a high potential for peptide engineering by introducing unusual amino acids into desired peptides, which may establish a universal approach to advance the structural design of novel peptides, termed lantibiotic engineering. In this review, we focus on recent development with contemporary innovations and perspective of lantibiotic research.

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalJournal of Bioscience and Bioengineering
Issue number3
Publication statusPublished - Sept 2006

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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