L-myc restriction fragment length polymorphism in Japanese patients with esophageal cancer

Kenji Shibuta, Hiroshi Inoue, Koichi Sato, Ayumi Matsuyama, Hiroaki Ueo, Youichi Tanaka, Kenichi Mafune, Graham F. Barnard, Masaki Mori

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17 Citations (Scopus)


L-myc polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there have been no reports concerning the association between esophageal cancer and L-myc polymorphism. To analyze the distribution of polymorphism in Japanese patients with esophageal cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used. Based on an analysis of 65 Japanese patients with esophageal cancer and 107 healthy control subjects, a significant difference was observed in either the distribution of genotypes (P = 0.012) or of allele frequencies between the two groups (P = 0.004). The relative risk of esophageal cancer for genotypes including the shorter allele was 2.9 compared to the longer allele homozygote. Furthermore, the patients with S-allele had a tendency for poor prognosis among those with three genotypes. A significant difference between the distribution of genotypes and the incidence of lymph node metastasis was found based on the clinicopathological features of the cancers. These results suggest that L-myc polymorphism may be implicated as a genetic trait affecting an individual's susceptibility to esophageal cancer, at least among Japanese patients.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJapanese Journal of Cancer Research
Issue number2
Publication statusPublished - Feb 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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