Kinetic Modeling of an Enzyme Membrane Reactor for the Selective Production of Oligosaccharides

Shusaku Asano, Yosuke Muranaka, Taisuke Maki, Koki Ikeda, Kazuhiro Mae

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


An enzyme membrane reactor is an attractive tool for producing oligosaccharides from biomass-based polysaccharides. However, kinetic modeling and reactor design based on the rate equations have rarely been reported for enzyme membrane reactors because of the difficulty in tracing the depolymerization process. In this study, a simplified reaction model based on Michaelis–Menten-type kinetics has been built to simulate the enzyme membrane reactor. Ramping various species into reactant, target, and byproduct worked well for discussing reactor performance. The use of a membrane with a molecular weight cut-off (MWCO) of 10 kDa with continuous feeding of the reactant was suggested for the efficient production of chitosan hexamer and pentamer by enzymatic hydrolysis of chitosan.

Original languageEnglish
Article number701
Issue number12
Publication statusPublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Plant Science


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